Cayo Largo del Sur is located right in the center of the Caribbean Sea, to the far east of the Los Cannareos archipelago and to the north east of the Cayman Islands. Its surface area is 37.5 square kilometers, while it is 25 kilometers long, almost all of which is beach. It is situated at a distance of 135 km from Nueva Gerona (Isle of Youth), 125 km from Cienfuegos, 177 km from Havana and 177 km from Varadero.

Cayo Largo has the advantage and privilege of being adjacent to Cayo Rico, Cayo Cantiles and Cayo Iguana, which are also of unsurpassable beauty and comprise, together with the Isle of Youth, the Los Canarreos archipelago